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Other Antiangiogenic Treatment Strategies
AMG 386
Another angiogenesis inhibitor with a unique mechanism of action being evaluated for ovarian cancer is AMG 386. This intravenously administered drug targets the angiogenesis-promoting proteins angiopoietin-1 and -2 and their receptor Tie-218. A recent phase 2 clinical study showed that adding AMG 386 to paclitaxel chemotherapy improved PFS by almost 3 months compared with placebo19. AMG 386 is now being evaluated in a randomized, placebo-controlled phase 3 trial called TRINOVA-1 to determine whether adding this agent to chemotherapy improves PFS in women with ovarian cancer that has recurred following chemotherapy20.


Last updated July 5, 2011