Cancers of the colon and rectum, together known as colorectal cancer (CRC), is the second leading cause of cancer-related death in the United States after lung cancer. An estimated 141,210 new cases and 49,380 deaths from the disease are estimated for 2011.¹ Better early detection and improved chemotherapy to treat advanced CRC have prolonged life expectancy in recent years. These improvements, however, have come at the cost of increasingly complex and toxic chemotherapy regimens, which often compromises patient quality of life.